A leak pathway for luminal protons in endosomes drives oncogenic signalling in glioblastoma

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1 a) As a continuation to the paper you were assigned to read ( i.e. for the next paper), what do you think should be the next research question and why? (Â 5 points) ( Please be brief in your answer, keeping it to a maximum of 1 short paragraph)

b) If you were working with this research group, what cellular mechanism/ mechanisms would you specifically test to address the research question proposed in 1a. (above)? (Â 3 points) ( Please be brief in your answer, keeping it to a maximum of 1 short paragraph)

c) How would you test the mechanism you proposed in 1b ( above)? Briefly discuss at least one experiment ( design a specific experiment or experiments). (2 points)

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2. Please write a critique of the paper you read, using the guidelines provided in the “research critique” sheet provided earlier. (10 points)

please answer those questionÂ

I need proffesional no plaigerism, its an upper level classÂ

in question two follow the attached document instructions please.Â