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Hospitalisation and major surgery may require for the treatment of the direct toxic effects of the drugs. Toxicology is the study of the nature, effects and detection of poisons and the treatment of poisoning, it can be harmful if administered inappropriately (Wong & Irwin, 2013). The anaesthetic agents may be administered by the inhaled route, intravenous, intramuscular, oral, topical, or rectal. The toxicity of aesthetic agents can be localized or systemic toxic, the localized adverse effects of aesthetic agents include neurovascular manifestations such as prolonged anaesthesia and paraesthesia, which may become irreversible. The Systemic toxicity of anaesthetics most often involves the central nervous system (CNS) and the cardiovascular system. The common symptom of systemic toxicity symptoms of CNS such as tongue numbness, Metallic taste, Light-headedness, Dizziness, Visual and auditory disturbances, Disorientation, and Drowsiness. With a severe complication can cause CNS depression with a cessation of convulsions Muscle twitching, Cardiovascular depression, and collapse. Furthermore, the common symptom of the systemic toxicity effects cardiovascular such as Chest pain, Shortness of breath, Palpitations, Hypotension, and Syncope (Kapitanyan, 2016).
As we know the toxicity chemical of a general anaesthetic suppresses the electrical activity and slows down activity of the brain. Therefore, the post-operative cognitive decline (POCD), memory loss and behaviour changes is part of the aesthetic reaction. The severe complications and death incident has been reduced rapidly due to the drugs and anaesthetists’ skills improved (Elkins, 2013). However, the difference in anaesthesia and the difference in numbers receiving general anaesthetics are accountable for increasing risk of permanent POCD several years after general anaesthesia. Therefore, preoperative screening management essential all patient especially young child and elderly patients. There are many question asking; Does the aesthetic can increase the permeant memory loss or developing dementia later in life?